Application to Use Human Research Subjects Essay

Application to wasting disease Human Research Subjects - Essay Example get a line and call Dept. Phone, E-mail address 3. Non-key personnel Name and Title Dept. Phone, E-mail address 7. Consultants Name and Title Dept. Phone, E-mail address 8. The principal investigator agrees to carry out the proposed project as stated in the application and to promptly report to the Human Subjects Committee any proposed changes and/or unanticipated problems involving risks to subjects or others active in approved project in accordance with the Liberty Way and the mysticality Statement. The principal investigator has gravel to copies of 45 CFR 46 and the Belmont Report. The principal investigator agrees to inform the Human Subjects Committee and complete all needed reports should the principal investigator terminate friendship with the University. Additionally s/he agrees to maintain records and keep cognizant consent documents for three years after completion of the project even if th e principal investigator terminates association with the University. ___________________________________ _________________________________________ Principal Investigator Signature fitting ___________________________________ _________________________________________ Faculty Sponsor (If applicable) Date Submit the original beg to Liberty University Institutional Review Board, CN Suite 1582, 1971 University Blvd., Lynchburg, VA 24502. Submit also via email to irbliberty.edu APPLICATION TO USE valet RESEARCH SUBJECTS 10. This project will be conducted at the following location(s) (please indicate city & state) Liberty University Campus X other(a) (Specify) Charlottesville High School Charlottesville, Virginia 11. This project will involve the following subject types (check-mark types to be studied) X Normal Volunteers (Age 18-65) Subjects Incapable Of Giving Consent In Patients Prisoners Or Institutionalized Individuals Out Patients X minor league (Under Age 18) Patient Contro ls Over Age 65 Fetuses University Students (PSYC Dept. subject pool __) Cognitively Disabled Other Potentially Elevated Risk Populations______ Physically Disabled __________________________________________ Pregnant Women Subjects Incapable of Giving Consent. 12. Do you conceive to use LU students, staff or faculty as participants in your study? If you do non intend to use LU participants in your study, please check no and proceed directly to level 13. YES NO X If Yes, please list the department and/or classes you hope to enlist and the number of participants you would interchangeable to enroll. In order to process your request to use LU subjects, we must ensure that you have contacted the suppress department and gained permission to collect data from them. Signature of Department Chair ___________________________________ ____________________________ Department Chair Signature(s) Date 13. Estimated number of subjects to be enrolled in this protocol ___15-25____________ 14. Does this project call for (check-mark all that apply to this study) X Use of Voice, Video, Digital, or Image Recordings? Subject Compensation? Patients $ Volunteers $ Participant Payment Disclosure Form Advertising For Subjects? much Than Minimal Risk? More Than Minimal Psychological Stress? Alcohol Consumption? X Confidential Material (questionnaires, photos, etc.)? Waiver of Informed Consent? Extra Costs To The Subjects (tests, hospitalization, etc.)? VO2 Max Exercise?

Gene Silencing at the Nuclear Periphery Essay Example | Topics and Well Written Essays - 1000 words

Gene Silencing at the Nuclear Periphery - Essay ExampleSome epigenetic abnormalities have been set in human tumors, offering tremendous scope for epigenetic modulation as part of cancer chemotherapy. (TY Kim, YJ Bang, KD Robertson, 2006)Hist angiotensin converting enzymes argon small, basic proteins which bind to DNA, to form nucleoproteins - this helps the DNA to be packed tightly into coiled coils. Histones atomic number 18 robust in the amino acids arginine and lysine. Unlike most proteins, histones are water soluble. The functions of histones include packing nucleoproteins for compaction, and chromatin regulation. Histones abide modifications this set of modifications which are interdependent and responsible for controlling gene activity is called the Histone code. The histone code speculation of gene regulation was articulated by David Allis and colleagues. According to this theory, expression of certain regions of DNA is moody on and off by histone code. Histone proteins are one of the most highly conserved proteins in eukaryotes, emphasise their importance in cell biology.Heterochromatin is the condensed, dense form of chromatin, which is transcriptionally in quick hence it is peripherally located. It is abundantly seen in resting or reserve cells. It stains deeply during interphase (resting stage). The heterochromatin part of a chromosome either lacks genes or has repressed genes. Heterochromatin is seen in twain pro and eukaryotes. Euchromatin is delicate, thread-like, active form of chromatin. It is abundant in active, transcribing cells. The importance of euchromatin is because the portion of the DNA coil think for transcription must uncoil, to permit reading of the code. It stains lightly and its gene concentration is high. It is usually under active transcription and hence it is partially or fully uncoiled. Prokaryotes have only euchromatin. NUCLEAR LOCALISATION - lineament IN GENE EXPRESSIONThe vital facts about gene silencing are (Shak lai et al, 2007) 1. Chromosomes rich in genes are centrally located in the nucleus. Conversely, gene poor ones are located in the periphery.2. Inactive genes are silenced and translocated to the periphery. 3. If chromatin is moved to the periphery, it is silenced and rendered inactive. Gene silencing plays an important role in determining the spate of different cell lines during development and defining their temporal order. (Fischer, Merkenschlager 2002)cDNA MICROARRAY TECHNIQUEcDNA microarray (c -complimentary) is a light beam which helps us analyze and measure the activity of genes. This is done using the process of molecular hybridization. Adenine and tetraiodothyronine are complimentary Guanine and cytosine are complimentary. While studying two pieces of DNA, if they hybridize (bind to one another), then we can conclude they are complimentary strands - opposite strands of a single gene. Conversely, if they do not hybridize, then they are unrelated.Microarray expression techni que has many applications - Gene expression profiling (comparing gene expressions in normal and abnormal cells), study of multigenic diseases like Parkinsons disease,detection of

Proteins Lab Report Example | Topics and Well Written Essays - 1250 words

Proteins - Lab Report ExampleProteins are essential nutrients and are therefore significant to the body, a factor that identifies the need to at a lower placestand their presence in substances for nutritional, and other, purposes. An understanding of protein levels in the body is also Copernican in determining changes from equilibrium fluid compositions. There are many ways in which protein densitys in substances, particularly solutions, can be situated. The most common approach is the application of a regression compend model to develop a relationship between protein parsimoniousness in a solution and absorbance ordain that can be experimentally defined. The developed relationship can then be theatrical roled to determine dousings of proteins in substances, under similar conditions, based on the absorption treasures in proteins from those solutions. This paper explores the use Bradford approach to determination of protein concentration. In order to use the approach to det ermine the concentrations, the paper tests the null meditation that there is no significant relationship between concentration of protein solutions and absorption rates. Applied research manner involved observation of experimental result from the Bradford approach to establish, analytically, existence of a relationship. The relationship is then utilize to determine concentration unknown proteins solutions. Analysis of the results identifies existence of a significant relationship. This is because of the small p cling to (p value= 0.000394) relative to the level of significance, 0.05. The paper therefore concludes validity of the method but identifies errors that lead to mismatched concentrations for the unknown solutions. Introduction and background information Protein quantification is an important biological concept with a wide chain of mountains of applications. This is majorly because proteins form fundamental structures of living cells and organs. This also identifies the need for understanding their importance in the body as well as the need for protein based nutrients. Identification of a specific level of need for protein components is for font important to nutritionists who need to know the recommended amount of proteins that an individual should take, a scope that identifies the need to understand protein concentration of different substances for recommendation of appropriate quantities that can be consumed. Knowledge of protein concentration can similarly be applied in health care environments to determine presence of diseases in a body (Chem, p. 105). The Bradfords approach to determination of protein concentration is one of the applicable techniques that is easy to apply and is time efficient (Mnstate, p. 1). It employs the spectrometry technology that uses light waves to determine concentration. The basis of application of the approach is absorption of a dye into protein (Clarke, p. 1). The jailed dye, whose concentration varies directly with the concentration of the absorbing protein then, forms the basis of determining the relationship between proteins concentration and absorbance property (Cuntapay, p. 1). The basis further relies on change in visibility of the used dye to determine the level of absorbance (Ruf, p. 1). The methods determination of the concentration of an unknown protein is further based on the precept that given similar conditions, such as the solvent and factors such as temperature, concentration of protein in a solution is the sole determinant of absorbance property. As a result, different proteins with similar concentrations will exhibit the very(prenominal) absorption rate if all other factors are constant. This further means that any other protein under the same conditions obeys a developed theory, in an equation of relationship between protein concentration and absorption rate (Thermo, p. 1). Such an equation is determined by regression analysis that establishes a relationship between pro tein concentration and absorption. The analysis, will in this case determine the rate of increase of absorption rate with each whole

Banned Books Essay Example | Topics and Well Written Essays - 750 words

Banned Books - Essay ExampleLikewise, key recitations forget be illustrated that show some of the common trends and underlying causes for both past and current security review that exists in the world. Furthermore, the reader will be able to understand key trends and underlying motives that encourage power structures to condition such a drastic approach to seeking to stamp out a given opinion/set of ideals. Perhaps one of the most famous examples of censorship is that which surrounded the Soviet Union and the communist party control that dominated nearly every aspect of public and private life. As a means of near total control over such a troupe, censorship was readily apply to direct and influence the way in which foreign ideas were injected into the society (Plamper 528). To accomplish this, the communist party employed a rigid structure whereby incoming literature and books would need to be approved by the applicable authorities prior to reaching encompassingspread dis persion. This structure of censorship is perhaps the most extreme example that our world has witnessed within the past 100 years however, it is not the only example of a society that has employed censorship, to great effect, in order to mould and direct, the social evolution of its populace. Similarly, censorship exists currently in a number of nations however, the lions sh ar of censorship in the current world is derived from a fear of the spread of a foreign religion within a host country and/or region. This is evidenced by strong censorship laws that exist in many Islamic countries. These laws ban everything from the distribution of religious material to immoral texts that can include anything from unislamic attitudes, styles of dress, forms of music and a host of other culturally derived points. A few of the countries that exhibit a high degree of censorship with regard to books and literature are Saudi Arabia, Eritrea and the Islamic Republic of Iran (Information Providers 100 ). A similar situation exists within what most readers might overturn a highly democratic country Germany. However, Germanys case is somewhat different than the other nations that nurture thus far been listed in this brief analysis. Germany has placed a ban on many of the national socialist era publications and propaganda pieces to include Adolph Hitlers Mein Kampf. According to pertinent government institutions and officials this has been done in order to reserve the populace a reprieve from the painful and harmful vitriol that was common and circulated around German a few brief decades ago. Germany of course is the aberration to the rule in that this is a nation that enjoys a wide array of democratic emancipations, elections, freedom of expression/thought and a wide range of freedom of row and freedoms of the press. However, as a function of the dangers that Nazism has presented the nation, they have chosen to implement a ban on all such material in the hope that doing so wi ll seek to hasten the meliorate of many war-era wounds that were caused as a direct effect of the policies and actions implemented by the Nazis government. Although the United States supposedly enjoys freedom of the press and freedom of thought, the United States itself has experienced a long and sordid past with relation to censorship. This censorship has primarily been concentric around education in that certain individuals, teachers, parents and/or government

Sulfur recovery processes Essay Example | Topics and Well Written Essays - 750 words

Sulfur recovery butt againstes - Essay exemplification blow treatment system, where the effluent gases that remain from the purification butt are used to oxidize atomic number 16 into sulfur dioxide, instead of being released to the atmosphere to cause pollution. Most significant is that this process yields high whole step sulfur, making it a good source of this valuable chemical (Kohl & Nielsen, 1997).However, the bloodline pollution controls that have been position in place have made the Claus process even more expensive, since well-nigh installations that prevent air pollution have to be made, despite the fact that they may not be economical at all. The problem of Claus Process is added to, by the fact that it is unable to fully convert hydrogen sulfide into elementary sulfur, due to some equilibrium limitations. Therefore, no matter how well the emission of sulfur compound is controlled, the process ends-up releasing relatively high quantities of the air pollutant than is actually acceptable (Kohl, 1997). Thus, most of the times, the process requires to be supplemented with specialized processes meant to remove the sulfur residue, which ensures that any excess sulfur emission from the process is cleaned-up.Claus process occurs in twain forms, referred to as the straight-through process and the split-flow process. The processes are differentiated by the fact that, while in the straight-through process gas is fed through the reaction furnace, it is fed directly into the major catalytic reactor through bypassing the furnace, in the split-flow process (Kohl & Nielsen, 1997). The choice of the process to be used between these two sulfur purification processes depends on the content of hydrogen sulfide in the gas to be purified, and whether the gas contains hydrocarbons. If the gas to be purified contains hydrocarbons, then, the straight-through process is opted for, while the split-flow process is applied where the gas does not contain large quantities of hydrocarbons (Kohl, 1997). There are some fundamental aspects of the Claus process that should

Consumers and the law Essay Example | Topics and Well Written Essays - 2500 words

Consumers and the law - Essay ExampleHe agrees to buy out a price reduction of 500 as well as the dealer being responsible for(p) for fixing the brakes. This does not bring about any other issue in the scenario so it would have the appearance _or_ semblance as though the dealers agreement to accept less as well as fix the problem would not be disputed. The amendment to initial offer would constitute as a condition, as defined in the case of Wallis v Pratt 1911 AC 394 asa condition is an obligation which goes so immediately to the substance of the contract, or in other words, is so essential to it very nature that its non-performance may more or less be considered by the other party, as a substantial failure to perform the contract at all.3Another operating issue that is important to note is if Amir is dealing as a consumer or operating in the course of business. The facts indicate that although he intends to use it mainly for personal use, he also intended to use it for business purposes, and more importantly, the purchase money came out of his business account. If the solicit determines that Amir is operating inside the course of business, he will not be protected on a lower floor the additional consumer protection given under s.48 Sale of Goods Act1979, as well as provisions contained within the Unfair Terms in Consumer Contracts Regulations 1999, among others.5 This issue becomes relevant with regards to the situation involving the clutch. Amir seems to be seeking rescission. thither are three problems with this is. The first issue is whether or not it can be seen that Amir is performing as a consumer. If it can be seen that Amir was acting as a consumer, he would be protected by s.48A(3) Sale of Goods Act which indicates that ...goods which do not conform to the contract of sale at any time within the period of six months starting with the date on which the goods were delivered to the buyer must be taken not to have so conformed

Fiscal Deficit and Economic Growth in an Economy Term Paper

financial dearth and Economic Growth in an Economy - Term Paper ExampleFiscal Deficit and Economic Growth in an EconomyIndia is a member nation of BRICS and the country is identified to be a developing economy. The country holds a global standing with respect to gross national overlap (GDP) and purchasing power parity (PPP). Multiple ups and down are identified within the economic organise of the country. However, despite of all the tediousness within its economic structure, the nation has projected remarkable survival instincts and has finally displayed an appreciable response against its economic and fiscal issues. Such situations often results in deteriorating the rate of economic reading as a result of the financial incapability of the government in context to spending more than on the economic developmental procedures. Irrespective of all these economic achievements, multiple economists in the present scenario realise still questioned regarding the fiscal stability of th is nation, which in the practical scenario can be considered to be on the threshold of collapsing (Kumar, 2014). The increased provision of government subsidies within public distribution services and sectors can be considered as the prime factors that has crippled the revenue generating capabilities of India. Understanding the gravity of the destabilizing economic and fiscal situation, the present government has shown its wide awake participation towards the implementation of appropriate fiscal modifications within the New Years budget.

Microorganisms in Nature and Biotechnology Essay

Microorganisms in Nature and Biotechnology - Essay ExampleThis research will begin with the statement that a micro-organism or hemipteran is an organism which is microscopic, usually too small to be seen by the naked eye. Microorganisms argon very various(a) including bacteria, fungi, archae, protists etc. They live in all parts of the biosphere where there is liquid water, including soil, warming springs, on the maritime floor, high in the atmosphere and deep inside the rocks within the Earths crust. Microbes are exact to nutrient recycle in ecosystem, biochemical and ecological cycles. They also play a major case in downfall and weather. Microbes are exploited in the fields of biotechnology, food technology, and genetic engineering. Even though most of the microorganisms are useful, a few are pathogenic too. A microorganism or microbe is an organism which is microscopic, usually too small to be seen by the naked eye. Microorganisms are very diverse including bacteria, fung i, archae, protists etc. They live in all parts of the biosphere where there is liquid water, including soil, hot springs, on the ocean floor, high in the atmosphere and deep inside the rocks within the Earths crust. Microbes are critical to nutrient recycling in ecosystem, biochemical and ecological cycles. They also play a major role in precipitation and weather. Microbes are exploited in the fields of biotechnology, food technology, and genetic engineering. Even though most of the microorganisms are useful, a few are pathogenic too. However, the recent developments of science have made the applications of microbes quite indispensable in the applied research of modern days.

A report (maximum of 1500 words) describing your current understanding Essay

A report (maximum of 1500 words) describing your current understanding of BIM (Building Information Modelling) and its drug abuse in the Civil Engineering - Essay ExampleThe processes associated with structure culture simulate (BMI) are associate to infrastructure and new buildings and have extended potential in refurbishment and retrofit projects especially when speedy energy analysis and laser scanning are employed. The technology associated with BMI is considered an association between software sedulousness and saying sectors with and aim at developing an environment for synergies and opportunities.Building information modeling aids in managing and generating data during construction life cycle. The approach utilizes real time, three dimensional and dynamic building modeling software to increase construction and building design productivity. The process has gives rise to BMI (Building information model) which encompasses spatial relationships, building geometry, geographic information, properties and quantities of building components. Building information modeling has various benefits such as modify visualization, cut back costs, increased productivity as a result of easy access to information, and improved delivery speed, improved coordination of documents associated with construction and linking and embedding of vital information for instance location of details, vendors of specific materials and quantities required for tendering and estimation (Crotty, 2012).Building information modeling extends beyond the computer assisted design and software since it involves designing and shaping. It is an architectural process that entails construction and virtual design and connects and integrates information by utilization of technology. BMI software such as Revit, Tekla and Microstation allows construction of a three dimensional model by the design team. The virtual approach integrates structural, electrical, mechanical and architectural. The process appli es to interior(a) fit out, master planning, infrastructure projects and building architecture. During the phase of construction, building